The AUC 0- t and AUC 0–∞ was remarkably increased the Cl was decreased when coadministrated with GFJ. The results showed that the AUC t –∞ was significantly increased when coadministrated with CRP. A high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was established to identify the chemical components in CRP decoction and GFJ. After a single intragastric administration of 6.0 mg/kg, the concentration of omeprazole in the plasma was determined by high-performance liquid chromatography (HPLC), and the pharmacokinetic parameters were calculated by Kinetica software 5.0. Sprague–Dawley rats were pretreated with CRP decoction or GFJ for 28 consecutive days. The effects of Citri Reticulatae Pericarpium (CRP) and grapefruit juice (GFJ) on the pharmacokinetics of omeprazole were investigated in this study.
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